6HZU
HUMAN JAK1 IN COMPLEX WITH LASW1393
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK1 | polymer | 302 | 34746.6 | 2 | UniProt (P23458) Pfam (PF07714) | Homo sapiens | Janus kinase 1,JAK-1 |
| 2 | C, D (A, B) | 2-[4-[8-oxidanylidene-2-[(~{E})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{H}-purin-9-yl]cyclohexyl]ethanenitrile | non-polymer | 363.4 | 2 | Chemie (GYQ) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 320 | Chemie (HOH) |
Sequence modifications
A, B: 854 - 1154 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Gly 853 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69493.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 726.7 | |
| All* | Total formula weight | 70219.9 |
