6HXK
Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ATP-citrate synthase | polymer | 270 | 30008.0 | 4 | UniProt (P53396) Pfam (PF00285) | Homo sapiens (Human) | ATP-citrate (pro-S-)-lyase,ACL,Citrate cleavage enzyme |
| 2 | E, H, K, M (A, B, C, D) | CITRATE ANION | non-polymer | 189.1 | 4 | Chemie (FLC) | |||
| 3 | F, G, O (A, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | I, N (B, D) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 5 | J (C) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 6 | L (C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 593 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 836 - 1101 (UniProt: P53396)
| PDB | External Database | Details |
|---|---|---|
| Gly 832 | - | expression tag |
| Ser 833 | - | expression tag |
| His 834 | - | expression tag |
| Met 835 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 120032.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1587.3 | |
| All* | Total formula weight | 121619.4 |
