6HWM

Structure of Thermus thermophilus ClpP in complex with bortezomib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	ATP-dependent Clp protease proteolytic subunit	polymer	204	22763.1	7	UniProt (Q5SKM8) Pfam (PF00574)	Thermus thermophilus	Endopeptidase Clp
2	H, I, J, L, M... (A, B, C, D, E...)	N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE	non-polymer		384.2	7	Chemie (BO2)
3	K, N, Q (C, E, G)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)

Sequence modifications

A, B, C, D, E, F, G: 1 - 194 (UniProt: Q5SKM8)

PDB	External Database	Details
Leu 195	-	expression tag
Glu 196	-	expression tag
His 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	159341.7
Non-Polymers*	Number of molecules	10
	Total formula weight	3008.0
All*	Total formula weight	162349.8

*Water molecules are not included.