6HWH
Structure of a functional obligate respiratory supercomplex from Mycobacterium smegmatis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, N (A, B) | Ubiquinol-cytochrome c reductase iron-sulfur subunit | polymer | 408 | 44869.4 | 2 | UniProt (A0R051) Pfam (PF19297) Pfam (PF00355) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| 2 | B, O (G, C) | Co-purified unknown transmembrane helices built as polyALA | polymer | 74 | 6315.8 | 2 | Mycobacterium smegmatis MC2 155 | ||
| 3 | C, P (H, D) | Co-purified unknown transmembrane helices built as polyALA | polymer | 65 | 5549.8 | 2 | Mycobacterium smegmatis MC2 155 | ||
| 4 | D, Q (I, E) | Co-purified unknown peptide built as polyALA | polymer | 20 | 1720.1 | 2 | Mycobacterium smegmatis MC2 155 | ||
| 5 | E, R (J, F) | Co-purified unknown peptide built as polyALA | polymer | 35 | 2996.7 | 2 | Mycobacterium smegmatis MC2 155 | ||
| 6 | AA, BA, F, S (M, K, i, j) | Cytochrome bc1 complex cytochrome c subunit | polymer | 268 | 27874.5 | 4 | UniProt (A0R050) Pfam (PF00034) Pfam (PF13442) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| 7 | G, T (P, L) | Cytochrome c oxidase subunit 2 | polymer | 341 | 38077.5 | 2 | UniProt (A0R057) Pfam (PF00116) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| 8 | H, U (R, N) | MSMEG_4693 | polymer | 79 | 8365.5 | 2 | UniProt (A0R1B6) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| 9 | I, V (T, O) | Uncharacterized protein MSMEG_4692/MSMEI_4575 | polymer | 157 | 15911.0 | 2 | UniProt (A0R1B5) Pfam (PF17174) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| 10 | J, W (V, Q) | Cytochrome c oxidase subunit 1 | polymer | 583 | 64841.6 | 2 | UniProt (A0R0M4) Pfam (PF00115) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| 11 | K, X (X, S) | Cytochrome c oxidase polypeptide 4 | polymer | 139 | 15177.4 | 2 | UniProt (A0R056) Pfam (PF12270) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | Cytochrome aa3 subunit 4,Cytochrome c oxidase polypeptide IV |
| 12 | L, Y (Z, W) | Cytochrome c oxidase subunit 3 | polymer | 203 | 22196.9 | 2 | UniProt (A0R049) Pfam (PF00510) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| 13 | M, Z (b, Y) | Ubiquinol-cytochrome C reductase QcrB | polymer | 554 | 61271.9 | 2 | UniProt (I7FGS8) Pfam (PF13631) UniProt (by SIFTS) (A0R052) | Mycobacterium smegmatis MC2 155 | |
| 14 | CA, RA (A, B) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 15 | BB, CB, DA, LA, OA... (Y, M, V, b, K...) | CARDIOLIPIN | non-polymer | 1464.0 | 8 | Chemie (CDL) | |||
| 16 | DB, EA, EB, QA (Y, M, b) | MENAQUINONE-9 | non-polymer | 785.2 | 4 | Chemie (MQ9) | |||
| 17 | FA, GA, JA, TA, UA... (P, V, L, Q) | COPPER (II) ION | non-polymer | 63.5 | 6 | Chemie (CU) | |||
| 18 | HA, IA, VA, WA (V, Q) | HEME-AS | non-polymer | 921.0 | 4 | Chemie (HAS) | |||
| 19 | FB, GB, HB, KA (i, j, V) | HEME C | non-polymer | 618.5 | 4 | Chemie (HEC) | |||
| 20 | AB, MA, NA, ZA (Y, b) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) |
Sequence modifications
b, Y: 1 - 546 (UniProt: I7FGS8)
| PDB | External Database | Details |
|---|---|---|
| Asp 547 | - | expression tag |
| Tyr 548 | - | expression tag |
| Lys 549 | - | expression tag |
| Asp 550 | - | expression tag |
| Asp 551 | - | expression tag |
| Asp 552 | - | expression tag |
| Asp 553 | - | expression tag |
| Lys 554 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 686085.5 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 24210.0 | |
| All* | Total formula weight | 710295.5 |
