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6HTY

PXR in complex with P2X4 inhibitor compound 25

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1polymer34439184.02UniProt (O75469)
UniProt (Q15788)
Pfam (PF00104)
Homo sapiens (Human)Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR,NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1
2C
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
3D, E, F, H, I
(A, B)
DIMETHYL SULFOXIDEnon-polymer78.15Chemie (DMS)
4G
(B)
(2~{R})-~{N}-[4-(3-chloranylphenoxy)-3-sulfamoyl-phenyl]-2-phenyl-propanamidenon-polymer430.91Chemie (GRH)
5J, K
(A, B)
waterwater18.0148Chemie (HOH)
Sequence modifications
A, B: 129 - 434 (UniProt: O75469)
PDBExternal DatabaseDetails
Met 119-initiating methionine
Lys 120-expression tag
Lys 121-expression tag
Gly 122-expression tag
His 123-expression tag
His 124-expression tag
His 125-expression tag
His 126-expression tag
His 127-expression tag
His 128-expression tag
Gly 129Lys 129cloning artifact
Gly 435-linker
Gly 436-linker
Ser 437-linker
Gly 438-linker
Gly 439-linker
A, B: 440 - 462 (UniProt: Q15788)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight78368.1
Non-Polymers*Number of molecules7
Total formula weight913.7
All*Total formula weight79281.7
*Water molecules are not included.

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PDB entries from 2025-07-30

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