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6HTS

Cryo-EM structure of the human INO80 complex bound to nucleosome

Replaces:  6ETX
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C, E
(A, C, E)
RuvB-like 1polymer45650296.93UniProt (Q9Y265)
Pfam (PF06068)
Pfam (PF17856)
Homo sapiens (Human)49 kDa TATA box-binding protein-interacting protein,49 kDa TBP-interacting protein,54 kDa erythrocyte cytosolic protein,ECP-54,INO80 complex subunit H,Nuclear matrix protein 238,NMP 238,Pontin 52,TIP49a,TIP60-associated protein 54-alpha,TAP54-alpha
2B, D, F
(B, D, F)
RuvB-like 2polymer46351222.53UniProt (Q9Y230)
Pfam (PF06068)
Pfam (PF17856)
Homo sapiens (Human)48 kDa TATA box-binding protein-interacting protein,48 kDa TBP-interacting protein,51 kDa erythrocyte cytosolic protein,ECP-51,INO80 complex subunit J,Repressing pontin 52,Reptin 52,TIP49b,TIP60-associated protein 54-beta,TAP54-beta
3G
(G)
Chromatin-remodeling ATPase INO80polymer1290146390.71UniProt (Q9ULG1)
Pfam (PF13892)
Pfam (PF00176)
Pfam (PF00271)
Homo sapiens (Human)hINO80,DNA helicase-related INO80 complex homolog 1,DNA helicase-related protein INO80,INO80 complex subunit A
4H
(H)
Actin-related protein 5polymer60768372.31UniProt (Q9H9F9)
Pfam (PF00022)
Homo sapiens (Human)hARP5,Sarcoma antigen NY-SAR-16
5I, M
(I, M)
Histone H3.1polymer13615437.22UniProt (P68431)
Pfam (PF00125)
Homo sapiens (Human)Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l
6J, N
(J, N)
Histone H4polymer10311394.42UniProt (P62805)
Pfam (PF15511)
Homo sapiens (Human)
7K, O
(K, O)
Histone H2A type 1-B/Epolymer13014165.62UniProt (P04908)
Pfam (PF00125)
Pfam (PF16211)
Homo sapiens (Human)Histone H2A.2,Histone H2A/a,Histone H2A/m
8L, P
(L, P)
Histone H2B type 1-Jpolymer12613935.22UniProt (P06899)
Pfam (PF00125)
Homo sapiens (Human)Histone H2B.1,Histone H2B.r,H2B/r
9Q
(R)
INO80 complex subunit Bpolymer35638704.21UniProt (Q9C086)
Pfam (PF04795)
Pfam (PF04438)
Homo sapiens (Human)High mobility group AT-hook 1-like 4,IES2 homolog,hIes2,PAP-1-associated protein 1,PAPA-1,Zinc finger HIT domain-containing protein 4
10R
(X)
DNA (150-MER)polymer22870604.91synthetic construct
11S
(Y)
DNA (150-MER)polymer22870199.61synthetic construct
12T, U, V, W, X...
(A, B, C, D, E...)
ADENOSINE-5'-DIPHOSPHATEnon-polymer427.26Chemie (ADP)
13Z
(R)
ZINC IONnon-polymer65.41Chemie (ZN)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains19
Total formula weight808694.7
Non-Polymers*Number of molecules7
Total formula weight2628.6
All*Total formula weight811323.3
*Water molecules are not included.

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PDB entries from 2025-06-11

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