6HTS

Cryo-EM structure of the human INO80 complex bound to nucleosome

Replaces:  6ETX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E	RuvB-like 1	polymer	456	50296.9	3	UniProt (Q9Y265) Pfam (PF06068) Pfam (PF17856) In PDB	Homo sapiens (Human)	49 kDa TATA box-binding protein-interacting protein,49 kDa TBP-interacting protein,54 kDa erythrocyte cytosolic protein,ECP-54,INO80 complex subunit H,Nuclear matrix protein 238,NMP 238,Pontin 52,TIP49a,TIP60-associated protein 54-alpha,TAP54-alpha
2	B, D, F	RuvB-like 2	polymer	463	51222.5	3	UniProt (Q9Y230) Pfam (PF06068) Pfam (PF17856) In PDB	Homo sapiens (Human)	48 kDa TATA box-binding protein-interacting protein,48 kDa TBP-interacting protein,51 kDa erythrocyte cytosolic protein,ECP-51,INO80 complex subunit J,Repressing pontin 52,Reptin 52,TIP49b,TIP60-associated protein 54-beta,TAP54-beta
3	G	Chromatin-remodeling ATPase INO80	polymer	1290	146390.7	1	UniProt (Q9ULG1) Pfam (PF13892) Pfam (PF00176) Pfam (PF00271) In PDB	Homo sapiens (Human)	hINO80,DNA helicase-related INO80 complex homolog 1,DNA helicase-related protein INO80,INO80 complex subunit A
4	H	Actin-related protein 5	polymer	607	68372.3	1	UniProt (Q9H9F9) Pfam (PF00022) In PDB	Homo sapiens (Human)	hARP5,Sarcoma antigen NY-SAR-16
5	I, M	Histone H3.1	polymer	136	15437.2	2	UniProt (P68431) Pfam (PF00125) In PDB	Homo sapiens (Human)	Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l
6	J, N	Histone H4	polymer	103	11394.4	2	UniProt (P62805) Pfam (PF15511) In PDB	Homo sapiens (Human)
7	K, O	Histone H2A type 1-B/E	polymer	130	14165.6	2	UniProt (P04908) Pfam (PF00125) Pfam (PF16211) In PDB	Homo sapiens (Human)	Histone H2A.2,Histone H2A/a,Histone H2A/m
8	L, P	Histone H2B type 1-J	polymer	126	13935.2	2	UniProt (P06899) Pfam (PF00125) In PDB	Homo sapiens (Human)	Histone H2B.1,Histone H2B.r,H2B/r
9	R	INO80 complex subunit B	polymer	356	38704.2	1	UniProt (Q9C086) Pfam (PF04795) Pfam (PF04438) In PDB	Homo sapiens (Human)	High mobility group AT-hook 1-like 4,IES2 homolog,hIes2,PAP-1-associated protein 1,PAPA-1,Zinc finger HIT domain-containing protein 4
10	X	DNA (150-MER)	polymer	228	70604.9	1		synthetic construct
11	Y	DNA (150-MER)	polymer	228	70199.6	1		synthetic construct
12	A, B, C, D, E...	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	6	Chemie (ADP)
13	R	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Contents of the asymmetric unit

Polymers	Number of chains	19
	Total formula weight	808694.7
Non-Polymers*	Number of molecules	7
	Total formula weight	2628.6
All*	Total formula weight	811323.3

*Water molecules are not included.