6HTR
Yeast 20S proteasome with human beta2c (S171G) in complex with 13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | PROTEASOME SUBUNIT ALPHA TYPE-2 | polymer | 250 | 27191.8 | 2 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 2 | B, P (B, P) | Proteasome subunit alpha type-3 | polymer | 258 | 28748.2 | 2 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit Y13,Multicatalytic endopeptidase complex subunit Y13,Proteasome component Y13,Proteinase YSCE subunit 13 |
| 3 | C, Q (C, Q) | PROTEASOME SUBUNIT ALPHA TYPE-4 | polymer | 254 | 28478.1 | 2 | UniProt (P40303) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 4 | D, R (D, R) | PROTEASOME SUBUNIT ALPHA TYPE-5 | polymer | 260 | 28649.1 | 2 | UniProt (P32379) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 5 | E, S (E, S) | PROTEASOME SUBUNIT ALPHA TYPE-6 | polymer | 234 | 25634.0 | 2 | UniProt (P40302) Pfam (PF00227) Pfam (PF10584) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 6 | F, T (F, T) | Probable proteasome subunit alpha type-7 | polymer | 288 | 31575.1 | 2 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit C1,Multicatalytic endopeptidase complex subunit C1,Proteasome component C1,Proteinase YSCE subunit 1 |
| 7 | G, U (G, U) | PROTEASOME SUBUNIT ALPHA TYPE-1 | polymer | 252 | 28033.8 | 2 | UniProt (P21243) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 8 | H, V (H, V) | Proteasome subunit beta type-7 | polymer | 234 | 25292.0 | 2 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) | Homo sapiens (Human) | Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z |
| 9 | I, W (I, W) | Proteasome subunit beta type-3 | polymer | 205 | 22627.8 | 2 | UniProt (P25451) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit PUP3,Multicatalytic endopeptidase complex subunit PUP3,Proteasome component PUP3 |
| 10 | J, X (J, X) | PROTEASOME SUBUNIT BETA TYPE-4 | polymer | 198 | 22545.7 | 2 | UniProt (P22141) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 11 | K, Y (K, Y) | Proteasome subunit beta type-5 | polymer | 212 | 23325.2 | 2 | UniProt (P30656) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit PRE2,Multicatalytic endopeptidase complex subunit PRE2,Proteasome component PRE2,Proteinase YSCE subunit PRE2 |
| 12 | L, Z (L, Z) | Proteasome subunit beta type-6 | polymer | 222 | 24883.9 | 2 | UniProt (P23724) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Multicatalytic endopeptidase complex subunit C5,Proteasome component C5 |
| 13 | AA, M (M, a) | Proteasome subunit beta type-7 | polymer | 246 | 27200.9 | 2 | UniProt (P30657) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit PRE4,Multicatalytic endopeptidase complex subunit PRE4,Proteasome component PRE4,Proteinase YSCE subunit PRE4 |
| 14 | BA, N (N, b) | PROTEASOME SUBUNIT BETA TYPE-1 | polymer | 196 | 21517.2 | 2 | UniProt (P38624) Pfam (PF00227) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 15 | CA, EA, FA, HA, IA... (G, H, I, K, N...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 16 | DA, GA, JA, LA (H, K, V, Y) | (2~{S})-~{N}-[(2~{S})-1-[[(2~{S})-1-[4-(aminomethyl)phenyl]-4-methylsulfonyl-butan-2-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]-2-[[(2~{S})-2-azido-3-phenyl-propanoyl]amino]-4-methyl-pentanamide | non-polymer | 629.8 | 4 | Chemie (GQT) | |||
| 17 | AB, BB, CB, DB, EB... (M, N, O, P, Q...) | water | water | 18.0 | 697 | Chemie (HOH) |
Sequence modifications
H, V: 1 - 234 (UniProt: Q99436)
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | Ser 214 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 731405.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2713.5 | |
| All* | Total formula weight | 734119.3 |
