6HSK
Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone deacetylase 8 | polymer | 380 | 42112.8 | 2 | UniProt (Q9BY41) Pfam (PF00850) | Homo sapiens (Human) | HD8 |
| 2 | C, G (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, H, I (A, B) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 4 | F, J (A, B) | 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide | non-polymer | 394.5 | 2 | Chemie (GOK) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 461 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 377 (UniProt: Q9BY41)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Ser 270 | Ala 270 | conflict |
| Arg 273 | Pro 273 | conflict |
| Leu 274 | Met 274 | conflict |
| Gly 275 | Cys 275 | conflict |
| Cys 276 | Ser 276 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84225.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1076.2 | |
| All* | Total formula weight | 85301.7 |
