6HR2
Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Transcription activator BRG1 | polymer | 120 | 14155.4 | 2 | UniProt (P51532) Pfam (PF00439) | Homo sapiens (Human) | ATP-dependent helicase SMARCA4,BRG1-associated factor 190A,BAF190A,Mitotic growth and transcription activator,Protein BRG-1,Protein brahma homolog 1,SNF2-beta,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 |
| 2 | B, F (B, F) | von Hippel-Lindau disease tumor suppressor | polymer | 149 | 17297.7 | 2 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
| 3 | C, G (C, G) | Elongin-C | polymer | 97 | 10974.6 | 2 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | D, H (D, H) | Elongin-B | polymer | 104 | 11748.4 | 2 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 5 | I, L (B, F) | (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 920.1 | 2 | Chemie (FWZ) | |||
| 6 | J, K (B, E) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 7 | M, N (F, H) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 8 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 404 | Chemie (HOH) |
Sequence modifications
C, G: 17 - 112 (UniProt: Q15369)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 108352.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2120.6 | |
| All* | Total formula weight | 110472.8 |
