6HP9
Structure of the kinase domain of human DDR1 in complex with a 2-Amino-2,3-Dihydro-1H-Indene-5-Carboxamide-based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Epithelial discoidin domain-containing receptor 1 | polymer | 315 | 35754.1 | 2 | UniProt (Q08345) Pfam (PF07714) In PDB | Homo sapiens (Human) | Epithelial discoidin domain receptor 1,CD167 antigen-like family member A,Cell adhesion kinase,Discoidin receptor tyrosine kinase,HGK2,Mammary carcinoma kinase 10,MCK-10,Protein-tyrosine kinase 3A,Protein-tyrosine kinase RTK-6,TRK E,Tyrosine kinase DDR,Tyrosine-protein kinase CAK |
| 2 | A, B | (2~{R})-~{N}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{H}-indene-5-carboxamide | non-polymer | 478.5 | 2 | Chemie (GKB) | |||
| 3 | water | water | 18.0 | 374 | Chemie (HOH) |
Sequence modifications
A, B: 601 - 913 (UniProt: Q08345)
| PDB | External Database | Details |
|---|---|---|
| Ser 599 | - | expression tag |
| Met 600 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71508.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 956.9 | |
| All* | Total formula weight | 72465.1 |
