6HMQ
STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE BENZOTRIAZOLE-TYPE INHIBITOR MB002
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Casein kinase II subunit alpha' | polymer | 364 | 42879.9 | 1 | UniProt (P19784) Pfam (PF00069) | Homo sapiens (Human) | |
| 2 | B (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 4 | M, N (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | O (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | P (A) | 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol | non-polymer | 492.8 | 1 | Chemie (4B0) | |||
| 7 | Q (A) | water | water | 18.0 | 399 | Chemie (HOH) |
Sequence modifications
A: 1 - 346 (UniProt: P19784)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Ser 336 | Cys 336 | engineered mutation |
| Thr 347 | - | expression tag |
| Ala 348 | - | expression tag |
| Ala 349 | - | expression tag |
| Arg 350 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42879.9 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1329.5 | |
| All* | Total formula weight | 44209.4 |
