6HKX

Eg5-inhibitor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Kinesin-like protein KIF11	polymer	368	41055.6	2	UniProt (P52732) Pfam (PF00225)	Homo sapiens (Human)	Kinesin-like protein 1,Kinesin-like spindle protein HKSP,Kinesin-related motor protein Eg5,Thyroid receptor-interacting protein 5,TRIP-5
2	C, G (A, B)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
3	D, H (A, B)	(2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl)phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide	non-polymer		420.5	2	Chemie (GCE)
4	E, I (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	F, J (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
6	K, L (A, B)	water	water		18.0	198	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	82111.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1956.2
All*	Total formula weight	84067.4

*Water molecules are not included.