6HKJ

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a inhibitor RNA 2-19-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutamate carboxypeptidase 2	polymer	707	79614.8	1	UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253)	Homo sapiens (Human)	Cell growth-inhibiting gene 27 protein,Folate hydrolase 1,Folylpoly-gamma-glutamate carboxypeptidase,FGCP,Glutamate carboxypeptidase II,GCPII,Membrane glutamate carboxypeptidase,mGCP,N-acetylated-alpha-linked acidic dipeptidase I,NAALADase I,Prostate-specific membrane antigen,PSMA,Pteroylpoly-gamma-glutamate carboxypeptidase
2	B, C (B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	D (D)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
4	E, F, G, H (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	I, J (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	K (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
7	L, O (A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
8	M (A)	TRIS(HYDROXYETHYL)AMINOMETHANE	non-polymer		163.2	1	Chemie (TAM)
9	N (A)	(2~{S})-2-[[(2~{S})-6-[(6-fluoranylpyridin-3-yl)amino]-1-oxidanyl-1,6-bis(oxidanylidene)hexan-2-yl]carbamoylamino]pentanedioic acid	non-polymer		428.4	1	Chemie (G8W)
10	P (A)	water	water		18.0	395	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	79614.8
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	11
	Total formula weight	1718.2
All*	Total formula weight	82930.5

*Water molecules are not included.