6HK3
Crystal structure of GSK-3B in complex with pyrazine inhibitor C44
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glycogen synthase kinase-3 beta | polymer | 350 | 39882.8 | 2 | UniProt (P49841) Pfam (PF00069) | Homo sapiens (Human) | GSK-3 beta,Serine/threonine-protein kinase GSK3B |
| 2 | C (N) | GLY-SER-HIS-GLY-HIS-HIS-HIS-HIS | polymer | 8 | 909.9 | 1 | Homo sapiens | ||
| 3 | D, K (A, B) | 3-azanyl-~{N}-(2-methoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamide | non-polymer | 482.6 | 2 | Chemie (G8B) | |||
| 4 | E, L (A, B) | MALONATE ION | non-polymer | 102.0 | 2 | Chemie (MLI) | |||
| 5 | F, G, H, M (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | I, N (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 7 | J, O (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 8 | P, Q, R (A, B, N) | water | water | 18.0 | 188 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 80675.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1764.8 | |
| All* | Total formula weight | 82440.2 |
