6HGT
Crystal structure of human KDM4A complexed with co-substrate analog NOG and histone H3 peptide with K9R mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Lysine-specific demethylase 4A | polymer | 360 | 41854.6 | 4 | UniProt (O75164) Pfam (PF02375) Pfam (PF02373) | Homo sapiens (Human) | JmjC domain-containing histone demethylation protein 3A,Jumonji domain-containing protein 2A |
| 2 | E, F, G, H (E, F, G, H) | Histone H3.3 | polymer | 15 | 1619.8 | 4 | UniProt (P84243) UniProt (by SIFTS) (P68431) | Homo sapiens (Human) | |
| 3 | I, J, L, M, O... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 4 | K, N, Q, T (A, B, C, D) | N-OXALYLGLYCINE | non-polymer | 147.1 | 4 | Chemie (OGA) | |||
| 5 | AA, BA, U, V, W... (G, H, A, B, C...) | water | water | 18.0 | 465 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 359 (UniProt: O75164)
E, F, G, H: 3 - 17 (UniProt: P84243)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Arg 9 | Lys 10 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 173897.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1111.6 | |
| All* | Total formula weight | 175009.5 |
