6HFP
Human dihydroorotase mutant F1563T co-crystallized with carbamoyl aspartate at pH 7.0
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CAD protein | polymer | 393 | 42855.9 | 1 | UniProt (P27708) Pfam (PF01979) | Homo sapiens (Human) | |
| 2 | B, C, D, E (A) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F (A) | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID | non-polymer | 158.1 | 1 | Chemie (DOR) | |||
| 4 | G, H, I, J (A) | FORMIC ACID | non-polymer | 46.0 | 4 | Chemie (FMT) | |||
| 5 | K (A) | water | water | 18.0 | 509 | Chemie (HOH) |
Sequence modifications
A: 1456 - 1846 (UniProt: P27708)
| PDB | External Database | Details |
|---|---|---|
| Gly 1454 | - | expression tag |
| Pro 1455 | - | expression tag |
| Gly 1513 | Ala 1513 | conflict |
| Thr 1563 | Phe 1563 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42855.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 603.8 | |
| All* | Total formula weight | 43459.8 |
