6H7N
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST XAMOTEROL AND NANOBODY Nb6B9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (E, F) | Thioredoxin 1 | polymer | 109 | 11784.4 | 2 | UniProt (P0AA25) Pfam (PF00085) | Escherichia coli (strain K12) | Trx-1 |
| 2 | B, D (A, B) | Beta-1 adrenergic receptor | polymer | 307 | 35002.8 | 2 | UniProt (P07700) Pfam (PF00001) | Meleagris gallopavo (turkey) | Beta-1 adrenoreceptor,Beta-T |
| 3 | E, F (C, D) | Camelid antibody fragment Nb6B9 | polymer | 121 | 13036.5 | 2 | Lama glama (llama) | ||
| 4 | G, M (A, B) | ~{N}-[2-[[(2~{S})-2-oxidanyl-3-(4-oxidanylphenoxy)propyl]amino]ethyl]morpholine-4-carboxamide | non-polymer | 339.4 | 2 | Chemie (FVK) | |||
| 5 | H, N (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | I, J, K, L, O (A, B) | HEGA-10 | non-polymer | 379.5 | 5 | Chemie (2CV) | |||
| 7 | P, Q, R, S, T (E, A, B, C, D) | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
E, F: 1 - 108 (UniProt: P0AA25)
A, B: 44 - 368 (UniProt: P07700)
| PDB | External Database | Details |
|---|---|---|
| Ser 32 | Cys 33 | engineered mutation |
| Ser 35 | Cys 36 | engineered mutation |
| Glu 109 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 39 | - | expression tag |
| Ala 40 | - | expression tag |
| Ala 41 | - | expression tag |
| Lys 42 | - | expression tag |
| Val 43 | - | expression tag |
| Ser 68 | Arg 68 | engineered mutation |
| Val 90 | Met 90 | engineered mutation |
| Leu 116 | Cys 116 | engineered mutation |
| - | Arg 243 | deletion |
| - | Cys 244 | deletion |
| - | Glu 245 | deletion |
| - | Gly 246 | deletion |
| - | Arg 247 | deletion |
| - | Phe 248 | deletion |
| - | Tyr 249 | deletion |
| - | Gly 250 | deletion |
| - | Ser 251 | deletion |
| - | Gln 252 | deletion |
| - | Glu 253 | deletion |
| - | Gln 254 | deletion |
| - | Pro 255 | deletion |
| - | Gln 256 | deletion |
| - | Pro 257 | deletion |
| - | Pro 258 | deletion |
| - | Pro 259 | deletion |
| - | Leu 260 | deletion |
| - | Pro 261 | deletion |
| - | Gln 262 | deletion |
| - | His 263 | deletion |
| - | Gln 264 | deletion |
| - | Pro 265 | deletion |
| - | Ile 266 | deletion |
| - | Leu 267 | deletion |
| - | Gly 268 | deletion |
| - | Asn 269 | deletion |
| - | Gly 270 | deletion |
| Lys 284 | Arg 284 | conflict |
| Ala 327 | Phe 327 | engineered mutation |
| Met 338 | Phe 338 | engineered mutation |
| Ala 358 | Cys 358 | engineered mutation |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
| His 373 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 119647.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2622.2 | |
| All* | Total formula weight | 122269.4 |
