6H4T
Crystal structure of human KDM4A in complex with compound 19a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Lysine-specific demethylase 4A | polymer | 360 | 41854.6 | 4 | UniProt (O75164) Pfam (PF02375) Pfam (PF02373) In PDB | Homo sapiens (Human) | JmjC domain-containing histone demethylation protein 3A,Jumonji domain-containing protein 2A |
| 2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | A, B, C, D | 8-[4-(2-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylethyl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one | non-polymer | 426.5 | 4 | Chemie (FOW) | |||
| 4 | A, B, C, D | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 5 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | D, B, C | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 6 | Chemie (DMS) | |||
| 7 | water | water | 18.0 | 749 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 359 (UniProt: O75164)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 167418.5 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2932.0 | |
| All* | Total formula weight | 170350.5 |
