6H37

The crystal structure of human carbonic anhydrase VII in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Carbonic anhydrase 7	polymer	274	30925.7	1	UniProt (P43166) Pfam (PF00194)	Homo sapiens (Human)	Carbonate dehydratase VII,Carbonic anhydrase VII,CA-VII
2	B (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	C (A)	4-(4-oxidanyl-4-phenyl-piperidin-1-yl)carbonylbenzenesulfonamide	non-polymer		360.4	1	Chemie (FKQ)
4	D (A)	water	water		18.0	115	Chemie (HOH)

Sequence modifications

A: -1 - 262 (UniProt: P43166)

PDB	External Database	Details
Met -3	-	expression tag
Gly -2	-	expression tag
Ser 183	Cys 185	engineered mutation
Ser 217	Cys 219	engineered mutation
Leu 263	-	expression tag
Glu 264	-	expression tag
His 265	-	expression tag
His 266	-	expression tag
His 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	30925.7
Non-Polymers*	Number of molecules	2
	Total formula weight	425.8
All*	Total formula weight	31351.5

*Water molecules are not included.