6H02

Crystal structure of human Mediator subunit MED23

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mediator of RNA polymerase II transcription subunit 23	polymer	1382	158294.9	1	UniProt (Q9ULK4) Pfam (PF11573) In PDB	Homo sapiens (Human)	Activator-recruited cofactor 130 kDa component,ARC130,Cofactor required for Sp1 transcriptional activation subunit 3,CRSP complex subunit 3,Mediator complex subunit 23,Protein sur-2 homolog,hSur-2,Transcriptional coactivator CRSP130,Vitamin D3 receptor-interacting protein complex 130 kDa component,DRIP130
2	B	LAMA nanobody NB106	polymer	134	14753.4	1		Lama glama

Sequence modifications

A: 1 - 1368 (UniProt: Q9ULK4)

PDB	External Database	Details
Asp 1369	-	expression tag
Val 1370	-	expression tag
Leu 1371	-	expression tag
Phe 1372	-	expression tag
Gln 1373	-	expression tag
Gly 1374	-	expression tag
Pro 1375	-	expression tag
Gly 1376	-	expression tag
His 1377	-	expression tag
His 1378	-	expression tag
His 1379	-	expression tag
His 1380	-	expression tag
His 1381	-	expression tag
His 1382	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	173048.3
All*	Total formula weight	173048.3

*Water molecules are not included.