6GZH
Crystal Structure of Human CDK9/cyclinT1 with A86
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 9 | polymer | 326 | 37598.6 | 1 | UniProt (P50750) Pfam (PF00069) | Homo sapiens (Human) | C-2K,Cell division cycle 2-like protein kinase 4,Cell division protein kinase 9,Serine/threonine-protein kinase PITALRE,Tat-associated kinase complex catalytic subunit |
| 2 | B (B) | Cyclin-T1 | polymer | 726 | 80728.7 | 1 | UniProt (O60563) Pfam (PF00134) Pfam (PF21797) | Homo sapiens (Human) | Cyclin-T |
| 3 | C (A) | [4-[[4-[5-(cyclopropylmethyl)-1-methyl-pyrazol-4-yl]-5-fluoranyl-pyrimidin-2-yl]amino]cyclohexyl]azanium | non-polymer | 345.4 | 1 | Chemie (LCI) | |||
| 4 | D, E (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
B: 1 - 726 (UniProt: O60563)
| PDB | External Database | Details |
|---|---|---|
| Arg 77 | Gln 77 | engineered mutation |
| Gly 96 | Glu 96 | engineered mutation |
| Leu 241 | Phe 241 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 118327.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 529.6 | |
| All* | Total formula weight | 118856.9 |
