6GYT

Transcription factor dimerization activates the p300 acetyltransferase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone acetyltransferase p300	polymer	161	18971.0	1	UniProt (Q09472) Pfam (PF00439) Pfam (PF06001)	Homo sapiens (Human)	p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein propionyltransferase p300
2	B (B)	Histone acetyltransferase p300	polymer	168	19586.7	1	UniProt (Q09472) Pfam (PF00439) Pfam (PF06001)	Homo sapiens (Human)	p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein propionyltransferase p300
3	C (C)	Histone H4	polymer	9	842.0	1	UniProt (by SIFTS) (P62799)	Xenopus laevis (African clawed frog)
4	D, E, F, G (A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	H, I (A, B)	water	water		18.0	36	Chemie (HOH)

Sequence modifications

A: 1047 - 1168 (UniProt: Q09472)

PDB	External Database	Details
Gly 1169	-	expression tag
Glu 1242	-	expression tag
Leu 1243	-	expression tag
Phe 1244	-	expression tag
Val 1245	-	expression tag
Glu 1246	-	expression tag
Cys 1247	-	expression tag
Thr 1248	-	expression tag
Glu 1249	-	expression tag
Cys 1250	-	expression tag
Gly 1251	-	expression tag
Arg 1252	-	expression tag
Lys 1253	-	expression tag
Met 1254	-	expression tag
His 1255	-	expression tag
Gln 1256	-	expression tag
Ile 1257	-	expression tag
Cys 1258	-	expression tag
Val 1259	-	expression tag
Leu 1260	-	expression tag
His 1261	-	expression tag
His 1262	-	expression tag
Glu 1263	-	expression tag
Ile 1264	-	expression tag
Ile 1265	-	expression tag
Trp 1266	-	expression tag
Pro 1267	-	expression tag
Ala 1268	-	expression tag
Gly 1269	-	expression tag
Phe 1270	-	expression tag
Val 1271	-	expression tag
Cys 1272	-	expression tag
Asp 1273	-	expression tag
Gly 1274	-	expression tag
Cys 1275	-	expression tag
Leu 1276	-	expression tag
Lys 1277	-	expression tag
Lys 1278	-	expression tag
Ser 1279	-	expression tag

B: 1047 - 1168 (UniProt: Q09472)

PDB	External Database	Details
Ala 1045	-	expression tag
Gly 1046	-	expression tag
Ala 1048	Ile 1048	conflict
Ala 1137	Arg 1137	conflict
Gly 1241	-	expression tag
Glu 1242	-	expression tag
Leu 1243	-	expression tag
Phe 1244	-	expression tag
Val 1245	-	expression tag
Glu 1246	-	expression tag
Cys 1247	-	expression tag
Thr 1248	-	expression tag
Glu 1249	-	expression tag
Cys 1250	-	expression tag
Gly 1251	-	expression tag
Arg 1252	-	expression tag
Lys 1253	-	expression tag
Met 1254	-	expression tag
His 1255	-	expression tag
Gln 1256	-	expression tag
Ile 1257	-	expression tag
Cys 1258	-	expression tag
Val 1259	-	expression tag
Leu 1260	-	expression tag
His 1261	-	expression tag
His 1262	-	expression tag
Glu 1263	-	expression tag
Ile 1264	-	expression tag
Ile 1265	-	expression tag
Trp 1266	-	expression tag
Pro 1267	-	expression tag
Ala 1268	-	expression tag
Gly 1269	-	expression tag
Phe 1270	-	expression tag
Val 1271	-	expression tag
Cys 1272	-	expression tag
Asp 1273	-	expression tag
Gly 1274	-	expression tag
Cys 1275	-	expression tag
Leu 1276	-	expression tag
Lys 1277	-	expression tag
Lys 1278	-	expression tag
Ser 1279	-	expression tag
Ala 1280	-	expression tag
Arg 1281	-	expression tag
Thr 1282	-	expression tag
Arg 1283	-	expression tag
Lys 1284	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	39399.6
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	39661.3

*Water molecules are not included.