6GYO
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | polymer | 521 | 60836.8 | 4 | UniProt (Q9Y3Q4) Pfam (PF08412) Pfam (PF00520) Pfam (PF00027) | Homo sapiens (Human) | |
| 2 | E, FA, SA, T (A, C, D, B) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 4 | Chemie (CMP) | |||
| 3 | BA, DA, EA, F, G... (B, C, A, D) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 28 | Chemie (PC1) | |||
| 4 | J, KA, XA, Y (A, C, D, B) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol | non-polymer | 836.1 | 4 | Chemie (PIE) | |||
| 5 | AA, K, L, LA, MA... (B, A, C, D) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 8 | Chemie (3PE) | |||
| 6 | CA, OA, P, Q (C, D, A, B) | UNKNOWN LIGAND | non-polymer | 65.4 | 4 | Chemie (UNX) |
Sequence modifications
A, B, C, D: 201 - 719 (UniProt: Q9Y3Q4)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 243347.0 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 33031.3 | |
| All* | Total formula weight | 276378.3 |
