6GYO
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | polymer | 521 | 60836.8 | 4 | UniProt (Q9Y3Q4) Pfam (PF08412) Pfam (PF00520) Pfam (PF00027) | Homo sapiens (Human) | |
| 2 | E, FA, SA, T (A, C, D, B) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 4 | Chemie (CMP) PubChem (23902375) PubChem (25322948) PubChem (176488666) PubChem (25322946) PubChem (40467852) PubChem (59350541) PubChem (44629928) PubChem (274) PubChem (6604194) PubChem (56973690) PubChem (163043517) PubChem (59909322) PubChem (59968988) PubChem (70878457) PubChem (6076) PubChem (124132380) PubChem (216878) PubChem (3080770) PubChem (3246347) PubChem (6603718) PubChem (6713792) PubChem (6714006) PubChem (129317551) PubChem (12071879) PubChem (12866365) PubChem (131841987) PubChem (134693155) PubChem (138107790) PubChem (163043518) | |||
| 3 | BA, DA, EA, F, G... (B, C, A, D) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 28 | Chemie (PC1) PubChem (94190) PubChem (10417837) PubChem (65146) | |||
| 4 | J, KA, XA, Y (A, C, D, B) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol | non-polymer | 836.1 | 4 | Chemie (PIE) PubChem (17754122) PubChem (49867502) PubChem (46936309) PubChem (71296231) | |||
| 5 | AA, K, L, LA, MA... (B, A, C, D) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 8 | Chemie (3PE) | |||
| 6 | CA, OA, P, Q (C, D, A, B) | UNKNOWN LIGAND | non-polymer | 65.4 | 4 | Chemie (UNX) |
Sequence modifications
A, B, C, D: 201 - 719 (UniProt: Q9Y3Q4)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 243347.0 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 33031.3 | |
| All* | Total formula weight | 276378.3 |
