6GXK
Crystal structure of Aldo-Keto Reductase 1C3 (AKR1C3) complexed with inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Aldo-keto reductase family 1 member C3 | polymer | 323 | 36896.2 | 2 | UniProt (P42330) Pfam (PF00248) In PDB | Homo sapiens (Human) | 17-beta-hydroxysteroid dehydrogenase type 5,17-beta-HSD 5,3-alpha-HSD type II,brain,3-alpha-hydroxysteroid dehydrogenase type 2,3-alpha-HSD type 2,Chlordecone reductase homolog HAKRb,Dihydrodiol dehydrogenase 3,DD3,Dihydrodiol dehydrogenase type I,HA1753,Indanol dehydrogenase,Prostaglandin F synthase,PGFS,Testosterone 17-beta-dehydrogenase 5,Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
| 2 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | A, B | 4-[[1-(4-chlorophenyl)carbonyl-5-methoxy-2-methyl-indol-3-yl]methyl]-1,2,5-oxadiazol-3-one | non-polymer | 397.8 | 2 | Chemie (FFW) | |||
| 4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 5 | water | water | 18.0 | 621 | Chemie (HOH) |
Sequence modifications
A, B: 6 - 323 (UniProt: P42330)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Asp 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Lys 4 | - | expression tag |
| Gln 5 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73792.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2530.7 | |
| All* | Total formula weight | 76323.1 |
