6GWN
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Plasminogen activator inhibitor 1 | polymer | 379 | 42780.0 | 1 | UniProt (P05121) Pfam (PF00079) | Homo sapiens (Human) | PAI-1,Endothelial plasminogen activator inhibitor,Serpin E1 |
| 2 | B (B) | VHH-2g-42 | polymer | 116 | 12752.3 | 1 | Vicugna pacos (alpaca) | ||
| 3 | C (C) | VHH-2w-64 | polymer | 121 | 13087.4 | 1 | Vicugna pacos (alpaca) | ||
| 4 | D, E, F (A, B, C) | water | water | 18.0 | 109 | Chemie (HOH) |
Sequence modifications
A: 1 - 379 (UniProt: P05121)
| PDB | External Database | Details |
|---|---|---|
| Phe 175 | Trp 198 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 68619.7 | |
| All* | Total formula weight | 68619.7 |
