6GWE
Crystal structure of Thrombin bound to P2 macrocycle
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, H) | Thrombin heavy chain | polymer | 259 | 29780.2 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (Human) | |
| 2 | B, D (L, B) | Thrombin light chain | polymer | 36 | 4096.5 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (Human) | |
| 3 | E, K (A, H) | (10S,14S,17R)-14-(3-carbamimidamidopropyl)-3-[[2-(hydroxymethyl)phenyl]methyl]-5,12,15-tris(oxidanylidene)-19-thia-3,6,13,16-tetrazatricyclo[19.4.0.0^{6,10}]pentacosa-1(21),22,24-triene-17-carboxamide | non-polymer | 666.8 | 2 | Chemie (ODB) | |||
| 4 | F, L (A, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | G, H, I, M (A, H) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | J, N (A, H) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | O, P, Q, R (A, L, H, B) | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 67753.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2070.3 | |
| All* | Total formula weight | 69823.8 |
