6GVX
Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Maternal embryonic leucine zipper kinase | polymer | 344 | 39723.1 | 2 | UniProt (Q14680) Pfam (PF00069) Pfam (PF21594) In PDB | Homo sapiens (Human) | hMELK,Protein kinase Eg3,pEg3 kinase,Protein kinase PK38,hPK38,Tyrosine-protein kinase MELK |
| 2 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 3 | A, B | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | non-polymer | 399.5 | 2 | Chemie (TAK) | |||
| 4 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 340 (UniProt: Q14680)
| PDB | External Database | Details |
|---|---|---|
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79446.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 923.1 | |
| All* | Total formula weight | 80369.3 |
