6GVJ

Human Mps1 kinase domain with ordered activation loop

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dual specificity protein kinase TTK	polymer	429	48872.6	1	UniProt (P33981) Pfam (PF00069)	Homo sapiens (Human)	Phosphotyrosine picked threonine-protein kinase,PYT
2	B, C, D, E, F... (A)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
3	H, I (A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	J (A)	water	water		18.0	30	Chemie (HOH)

Sequence modifications

A: 400 - 808 (UniProt: P33981)

PDB	External Database	Details
Met 380	-	initiating methionine
Ala 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
Ser 388	-	expression tag
Ala 389	-	expression tag
Ala 390	-	expression tag
Leu 391	-	expression tag
Glu 392	-	expression tag
Val 393	-	expression tag
Leu 394	-	expression tag
Phe 395	-	expression tag
Gln 396	-	expression tag
Gly 397	-	expression tag
Pro 398	-	expression tag
Gly 399	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	48872.6
Non-Polymers*	Number of molecules	8
	Total formula weight	623.5
All*	Total formula weight	49496.0

*Water molecules are not included.