6GUE

CDK2/CyclinA in complex with AZD5438

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cyclin-dependent kinase 2	polymer	302	34339.8	1	UniProt (P24941) Pfam (PF00069)	Homo sapiens (Human)	Cell division protein kinase 2,p33 protein kinase
2	B, D (B, D)	Cyclin-A2	polymer	268	30847.5	2	UniProt (P30274) Pfam (PF00134) Pfam (PF02984)	Bos taurus (cattle)	Cyclin-A
3	C (C)	Cyclin-dependent kinase 2	polymer	302	34354.8	1	UniProt (P24941) Pfam (PF00069)	Homo sapiens (Human)	Cell division protein kinase 2,p33 protein kinase
4	E, F (A, C)	4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine	non-polymer		371.5	2	Chemie (FB8)
5	G, H, I, J (A, B, C, D)	water	water		18.0	539	Chemie (HOH)

Sequence modifications

A: 1 - 298 (UniProt: P24941)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Asn 73	Glu 73	conflict

B, D: 171 - 432 (UniProt: P30274)

PDB	External Database	Details
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag

C: 1 - 298 (UniProt: P24941)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130389.5
Non-Polymers*	Number of molecules	2
	Total formula weight	742.9
All*	Total formula weight	131132.4

*Water molecules are not included.