6GQX

KRAS-169 Q61H GPPNHP + CH-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, D, E, F (A, C, D, E, F)	GTPase KRas	polymer	171	19519.0	5	UniProt (P01116) Pfam (PF00071)	Homo sapiens (Human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	B (B)	GTPase KRas	polymer	170	19355.8	1	UniProt (P01116) Pfam (PF00071)	Homo sapiens (Human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
3	G, J, M (A, B, C)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	H, K, N, P, Q... (A, B, C, D, E...)	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	6	Chemie (GNP)
5	I, L, O (A, B, C)	[4-[[2-methoxy-4-(3-methoxyphenyl)phenyl]amino]phenyl]methyl-dimethyl-azanium	non-polymer		363.5	3	Chemie (F8K)
6	S, T, U, V, W... (A, B, C, D, E...)	water	water		18.0	95	Chemie (HOH)

Sequence modifications

A, C, D, E, F: 1 - 167 (UniProt: P01116)

PDB	External Database	Details
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
His 61	Gln 61	engineered mutation

B: 1 - 167 (UniProt: P01116)

PDB	External Database	Details
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
His 61	Gln 61	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	116950.9
Non-Polymers*	Number of molecules	12
	Total formula weight	4296.5
All*	Total formula weight	121247.4

*Water molecules are not included.