6GQU

Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with cAMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Heat shock protein HSP 90-alpha	polymer	256	28801.2	1	UniProt (P07900) Pfam (PF13589)	Homo sapiens (Human)	Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38
2	B (A)	ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE	non-polymer		329.2	1	Chemie (CMP) PubChem (6076) PubChem (216878) PubChem (3080770) PubChem (3246347) PubChem (6603718) PubChem (6713792) PubChem (6714006) PubChem (12071879) PubChem (12866365) PubChem (23902375) PubChem (25322948) PubChem (40467852) PubChem (44629928) PubChem (176488666) PubChem (25322946) PubChem (59350541) PubChem (274) PubChem (6604194) PubChem (56973690) PubChem (163043517) PubChem (59909322) PubChem (59968988) PubChem (70878457) PubChem (124132380) PubChem (129317551) PubChem (131841987) PubChem (134693155) PubChem (138107790) PubChem (163043518)
3	C (A)	water	water		18.0	296	Chemie (HOH)

Sequence modifications

A: 1 - 236 (UniProt: P07900)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Arg 112	Lys 112	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	28801.2
Non-Polymers*	Number of molecules	1
	Total formula weight	329.2
All*	Total formula weight	29130.4

*Water molecules are not included.