6GQQ
Crystal structure of human KDR (VEGFR2) kinase domain in complex with AZD3229-analogue (compound 35)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Vascular endothelial growth factor receptor 2 | polymer | 322 | 36989.6 | 1 | UniProt (P35968) Pfam (PF07714) In PDB | Homo sapiens (Human) | VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase insert domain receptor,KDR,Protein-tyrosine kinase receptor flk-1,VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase insert domain receptor,KDR,Protein-tyrosine kinase receptor flk-1 |
| 2 | A | ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | non-polymer | 448.5 | 1 | Chemie (F8B) | |||
| 3 | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A: 806 - 939 (UniProt: P35968)
A: 941 - 1171 (UniProt: P35968)
A: 941 - 1171 (UniProt: P35968)
| PDB | External Database | Details |
|---|---|---|
| Val 940 | - | linker |
| Glu 1172 | - | expression tag |
| Asn 1173 | - | expression tag |
| Leu 1174 | - | expression tag |
| Tyr 1175 | - | expression tag |
| Phe 1176 | - | expression tag |
| Gln 1177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36989.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 448.5 | |
| All* | Total formula weight | 37438.1 |
