6GQO

Crystal structure of human KDR (VEGFR2) kinase domain in complex with AZD3229-analogue (compound 18)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Vascular endothelial growth factor receptor 2	polymer	322	36989.6	1	UniProt (P35968) Pfam (PF07714) In PDB	Homo sapiens (Human)	VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase insert domain receptor,KDR,Protein-tyrosine kinase receptor flk-1,VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase insert domain receptor,KDR,Protein-tyrosine kinase receptor flk-1
2	A	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide	non-polymer		477.5	1	Chemie (F82)
3		water	water		18.0	128	Chemie (HOH)

Sequence modifications

A: 806 - 939 (UniProt: P35968)
A: 941 - 1171 (UniProt: P35968)

PDB	External Database	Details
Val 940	-	linker
Glu 1172	-	expression tag
Asn 1173	-	expression tag
Leu 1174	-	expression tag
Tyr 1175	-	expression tag
Phe 1176	-	expression tag
Gln 1177	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36989.6
Non-Polymers*	Number of molecules	1
	Total formula weight	477.5
All*	Total formula weight	37467.1

*Water molecules are not included.