6GQL
Crystal structure of human c-KIT kinase domain in complex with AZD3229-analogue (compound 35)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mast/stem cell growth factor receptor Kit | polymer | 328 | 37332.6 | 2 | UniProt (P10721) Pfam (PF07714) | Homo sapiens (Human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| 2 | C, D (A, B) | ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | non-polymer | 448.5 | 2 | Chemie (F8B) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 298 | Chemie (HOH) |
Sequence modifications
A, B: 551 - 934 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Gly 547 | - | expression tag |
| Ser 548 | - | expression tag |
| His 549 | - | expression tag |
| Met 550 | - | expression tag |
| Ser 563 | Ile 563 | engineered mutation |
| Ser 569 | Val 569 | engineered mutation |
| Gln 609 | Tyr 609 | engineered mutation |
| Ser 631 | Leu 631 | engineered mutation |
| Glu 651 | Met 651 | engineered mutation |
| His 662 | Ile 662 | engineered mutation |
| Glu 688 | Ser 688 | conflict |
| Val 690 | Ile 690 | conflict |
| Pro 691 | Cys 691 | conflict |
| Tyr 692 | Ser 692 | conflict |
| - | Gln 694 | deletion |
| - | Glu 695 | deletion |
| - | Asp 696 | deletion |
| - | His 697 | deletion |
| - | Ala 698 | deletion |
| - | Glu 699 | deletion |
| - | Ala 700 | deletion |
| - | Ala 701 | deletion |
| - | Leu 702 | deletion |
| - | Tyr 703 | deletion |
| - | Lys 704 | deletion |
| - | Asn 705 | deletion |
| - | Leu 706 | deletion |
| - | Leu 707 | deletion |
| - | His 708 | deletion |
| - | Ser 709 | deletion |
| - | Lys 710 | deletion |
| - | Glu 711 | deletion |
| - | Ser 712 | deletion |
| - | Ser 713 | deletion |
| - | Cys 714 | deletion |
| - | Ser 715 | deletion |
| - | Asp 716 | deletion |
| - | Ser 717 | deletion |
| - | Thr 718 | deletion |
| - | Asn 719 | deletion |
| - | Glu 720 | deletion |
| - | Tyr 721 | deletion |
| - | Met 722 | deletion |
| - | Asp 723 | deletion |
| - | Met 724 | deletion |
| - | Lys 725 | deletion |
| - | Pro 726 | deletion |
| - | Gly 727 | deletion |
| - | Val 728 | deletion |
| - | Ser 729 | deletion |
| - | Tyr 730 | deletion |
| - | Val 731 | deletion |
| - | Val 732 | deletion |
| - | Pro 733 | deletion |
| - | Thr 734 | deletion |
| - | Lys 735 | deletion |
| - | Ala 736 | deletion |
| - | Asp 737 | deletion |
| - | Lys 738 | deletion |
| - | Arg 739 | deletion |
| - | Arg 740 | deletion |
| - | Ser 741 | deletion |
| - | Val 742 | deletion |
| - | Arg 743 | deletion |
| - | Ile 744 | deletion |
| - | Gly 745 | deletion |
| - | Ser 746 | deletion |
| - | Tyr 747 | deletion |
| - | Ile 748 | deletion |
| - | Glu 749 | deletion |
| - | Arg 750 | deletion |
| - | Asp 751 | deletion |
| - | Val 752 | deletion |
| - | Thr 753 | deletion |
| - | Pro 754 | deletion |
| Val 754 | Ala 755 | conflict |
| Ala 755 | Ile 756 | conflict |
| Pro 756 | Met 757 | conflict |
| Leu 759 | - | insertion |
| Tyr 760 | Asp 760 | conflict |
| Lys 761 | Glu 761 | conflict |
| Asp 762 | Leu 762 | conflict |
| Phe 763 | Ala 763 | conflict |
| Thr 765 | Asp 765 | conflict |
| His 768 | Asp 768 | engineered mutation |
| Asn 804 | Arg 804 | engineered mutation |
| Asp 825 | Val 825 | engineered mutation |
| Ser 844 | Cys 844 | engineered mutation |
| Ser 890 | Leu 890 | engineered mutation |
| Tyr 894 | His 894 | engineered mutation |
| Asp 912 | Leu 912 | engineered mutation |
| Asp 923 | Leu 923 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74665.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 896.9 | |
| All* | Total formula weight | 75562.1 |
