6GPK
Crystal structure of human GDP-D-mannose 4,6-dehydratase (E157Q) in complex with GDP-Man
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | GDP-mannose 4,6 dehydratase | polymer | 373 | 42527.1 | 4 | UniProt (O60547) Pfam (PF16363) In PDB | Homo sapiens (Human) | GDP-D-mannose dehydratase,GMD |
| 2 | C, A, D, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 28 | Chemie (EDO) | |||
| 3 | B, C, D, A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 4 | B, C, D, A | GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE | non-polymer | 605.3 | 4 | Chemie (GDD) | |||
| 5 | C | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 858 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 23 - 372 (UniProt: O60547)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| His 1 | - | expression tag |
| His 2 | - | expression tag |
| His 3 | - | expression tag |
| His 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| Ser 7 | - | expression tag |
| Ser 8 | - | expression tag |
| Gly 9 | - | expression tag |
| Val 10 | - | expression tag |
| Asp 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Gly 13 | - | expression tag |
| Thr 14 | - | expression tag |
| Glu 15 | - | expression tag |
| Asn 16 | - | expression tag |
| Leu 17 | - | expression tag |
| Tyr 18 | - | expression tag |
| Phe 19 | - | expression tag |
| Gln 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Met 22 | - | expression tag |
| Gln 157 | Glu 157 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 170108.6 | |
| Non-Polymers* | Number of molecules | 37 |
| Total formula weight | 7225.0 | |
| All* | Total formula weight | 177333.5 |
