6GNV
Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a isopropyl methyl indole aryl sulphonamide ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glycylpeptide N-tetradecanoyltransferase | polymer | 411 | 47263.9 | 1 | UniProt (Q4Q5S8) Pfam (PF01233) Pfam (PF02799) | Leishmania major | |
| 2 | B (A) | TETRADECANOYL-COA | non-polymer | 977.9 | 1 | Chemie (MYA) | |||
| 3 | C (A) | ~{N}-[2-methyl-5-(2-methylpropyl)indazol-4-yl]-4-[4-(1-methylpiperidin-4-yl)butyl]benzenesulfonamide | non-polymer | 496.7 | 1 | Chemie (F5E) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | water | water | 18.0 | 233 | Chemie (HOH) |
Sequence modifications
A: 11 - 421 (UniProt: Q4Q5S8)
| PDB | External Database | Details |
|---|---|---|
| Ala 233 | Ser 233 | conflict |
| Ala 235 | Ile 235 | conflict |
| Ala 240 | Gln 240 | conflict |
| Ala 241 | Lys 241 | conflict |
| Ala 243 | Gln 243 | conflict |
| Ala 336 | Ser 336 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 47263.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1566.7 | |
| All* | Total formula weight | 48830.5 |
