6GMH
Structure of activated transcription complex Pol II-DSIF-PAF-SPT6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RPB1 | polymer | 1970 | 217610.0 | 1 | Pfam (PF04997) Pfam (PF05001) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) Pfam (PF04992) Pfam (PF04990) UniProt (by SIFTS) (I3LJR4) | Sus scrofa (Pig) | |
| 2 | B (B) | DNA-directed RNA polymerase subunit beta | polymer | 1174 | 134041.4 | 1 | UniProt (I3LGP4) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) | Sus scrofa (Pig) | |
| 3 | C (C) | RNA polymerase II subunit C | polymer | 275 | 31439.1 | 1 | UniProt (I3LCH3) Pfam (PF01193) Pfam (PF01000) | Sus scrofa (Pig) | |
| 4 | D (D) | RNA polymerase II subunit D | polymer | 142 | 16331.3 | 1 | UniProt (A0A287ADR4) Pfam (PF03874) | Sus scrofa (Pig) | |
| 5 | E (E) | RNA polymerase II subunit E | polymer | 210 | 24644.3 | 1 | UniProt (I3LSI7) Pfam (PF03871) Pfam (PF01191) | Sus scrofa (Pig) | |
| 6 | F (F) | RNA polymerase II subunit F | polymer | 127 | 14477.0 | 1 | UniProt (F1SKN8) Pfam (PF01192) UniProt (by SIFTS) (A0A4X1VEK9) | Sus scrofa (Pig) | |
| 7 | G (G) | RNA polymerase II subunit G | polymer | 172 | 19314.3 | 1 | UniProt (I3LJZ9) | Sus scrofa (Pig) | |
| 8 | H (H) | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 150 | 17162.3 | 1 | UniProt (I3LCB2) Pfam (PF03870) | Sus scrofa (Pig) | |
| 9 | I (I) | DNA-directed RNA polymerase II subunit RPB9 | polymer | 125 | 14541.2 | 1 | UniProt (P60899) Pfam (PF02150) Pfam (PF01096) | Sus scrofa (Pig) | RNA polymerase II subunit B9,DNA-directed RNA polymerase II subunit I,RNA polymerase II 14.5 kDa subunit,RPB14.5 |
| 10 | J (J) | RPB10 | polymer | 67 | 7655.1 | 1 | Sus scrofa (Pig) | ||
| 11 | K (K) | RPB11 | polymer | 117 | 13310.3 | 1 | UniProt (F1RKE4) Pfam (PF13656) | Sus scrofa (Pig) | |
| 12 | L (L) | RPB12 | polymer | 58 | 7018.2 | 1 | UniProt (I3LN51) Pfam (PF03604) UniProt (by SIFTS) (A0A4X1TRS6) | Sus scrofa (Pig) | |
| 13 | M (M) | Transcription elongation factor SPT6,Transcription elongation factor SPT6,Transcription elongation factor SPT6 | polymer | 1726 | 198992.4 | 1 | UniProt (Q7KZ85) Pfam (PF14632) Pfam (PF14641) Pfam (PF22706) Pfam (PF14639) Pfam (PF14635) Pfam (PF17674) Pfam (PF00575) Pfam (PF14633) | Homo sapiens (Human) | hSPT6,Histone chaperone suppressor of Ty6,Tat-cotransactivator 2 protein,Tat-CT2 protein,hSPT6,Histone chaperone suppressor of Ty6,Tat-cotransactivator 2 protein,Tat-CT2 protein,hSPT6,Histone chaperone suppressor of Ty6,Tat-cotransactivator 2 protein,Tat-CT2 protein |
| 14 | N (N) | Non-template DNA | polymer | 48 | 14932.5 | 1 | synthetic construct | ||
| 15 | O (P) | RNA | polymer | 46 | 14843.9 | 1 | synthetic construct | ||
| 16 | P (Q) | CTR9,RNA polymerase-associated protein CTR9 homolog,RNA polymerase-associated protein CTR9 homolog | polymer | 1178 | 125713.3 | 1 | UniProt (Q6PD62) Pfam (PF13374) Pfam (PF13181) | Homo sapiens | SH2 domain-binding protein 1,SH2 domain-binding protein 1 |
| 17 | Q (T) | Template DNA | polymer | 48 | 14672.3 | 1 | synthetic construct | ||
| 18 | R (U) | LEO1,LEO1,RNA polymerase-associated protein LEO1 | polymer | 776 | 84875.8 | 1 | UniProt (Q8WVC0) Pfam (PF04004) | Homo sapiens | Replicative senescence down-regulated leo1-like protein |
| 19 | S (V) | PAF1,RNA polymerase II-associated factor 1 homolog,RNA polymerase II-associated factor 1 homolog | polymer | 613 | 67031.3 | 1 | UniProt (Q8N7H5) Pfam (PF03985) | Homo sapiens | hPAF1,Pancreatic differentiation protein 2,hPAF1,Pancreatic differentiation protein 2 |
| 20 | T (W) | WD repeat-containing protein 61 | polymer | 305 | 33617.5 | 1 | UniProt (Q9GZS3) Pfam (PF00400) | Homo sapiens (Human) | Meiotic recombination REC14 protein homolog,SKI8 homolog,Ski8 |
| 21 | U (X) | CDC73 | polymer | 16 | 1379.7 | 1 | Homo sapiens | ||
| 22 | V (Y) | Transcription elongation factor SPT4 | polymer | 121 | 13508.5 | 1 | UniProt (P63272) Pfam (PF06093) | Homo sapiens (Human) | hSPT4,DRB sensitivity-inducing factor 14 kDa subunit,DSIF p14,DRB sensitivity-inducing factor small subunit,DSIF small subunit |
| 23 | W (Z) | Transcription elongation factor SPT5 | polymer | 1087 | 121145.5 | 1 | UniProt (O00267) Pfam (PF11942) Pfam (PF03439) Pfam (PF00467) | Homo sapiens (Human) | hSPT5,DRB sensitivity-inducing factor 160 kDa subunit,DSIF p160,DRB sensitivity-inducing factor large subunit,DSIF large subunit,Tat-cotransactivator 1 protein,Tat-CT1 protein |
| 24 | AA, BA, CA, DA, EA... (B, C, I, J, L...) | ZINC ION | non-polymer | 65.4 | 9 | Chemie (ZN) | |||
| 25 | Z (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
M: 1 - 1326 (UniProt: Q7KZ85)
M: 1327 - 1334 (PDB: 6GMH)
M: 1338 - 1726 (UniProt: Q7KZ85)
Q: 1 - 300 (PDB: 6GMH)
Q: 301 - 1173 (UniProt: Q6PD62)
U: 371 - 529 (PDB: 6GMH)
U: 530 - 1195 (UniProt: Q8WVC0)
V: 198 - 338 (PDB: 6GMH)
V: 339 - 869 (UniProt: Q8N7H5)
Y: 1 - 117 (UniProt: P63272)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
M: 1338 - 1726 (UniProt: Q7KZ85)
Q: 1 - 300 (PDB: 6GMH)
Q: 301 - 1173 (UniProt: Q6PD62)
| PDB | External Database | Details |
|---|---|---|
| Glu 1174 | - | expression tag |
| Asn 1175 | - | expression tag |
| Leu 1176 | - | expression tag |
| Tyr 1177 | - | expression tag |
| Gln 1178 | - | expression tag |
U: 530 - 1195 (UniProt: Q8WVC0)
V: 198 - 338 (PDB: 6GMH)
V: 339 - 869 (UniProt: Q8N7H5)
Y: 1 - 117 (UniProt: P63272)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 23 |
| Total formula weight | 1208257.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 613.0 | |
| All* | Total formula weight | 1208870.1 |
