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6GLL

Crystal structure of hMTH1 N33A in complex with LW14 in the presence of acetate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B7,8-dihydro-8-oxoguanine triphosphatasepolymer18221061.92UniProt (P36639)
Pfam (PF00293)
In PDB
Homo sapiens (Human)2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1
2A, B1~{H}-imidazo[4,5-b]pyridin-2-aminenon-polymer134.12Chemie (BU8)
3A, BSULFATE IONnon-polymer96.14Chemie (SO4)
4A, BACETATE IONnon-polymer59.02Chemie (ACT)
5waterwater18.0410Chemie (HOH)
Sequence modifications
A, B: 1 - 156 (UniProt: P36639)
PDBExternal DatabaseDetails
Met -25-initiating methionine
Lys -24-expression tag
His -23-expression tag
His -22-expression tag
His -21-expression tag
His -20-expression tag
His -19-expression tag
His -18-expression tag
Pro -17-expression tag
Met -16-expression tag
Ser -15-expression tag
Asp -14-expression tag
Tyr -13-expression tag
Asp -12-expression tag
Ile -11-expression tag
Pro -10-expression tag
Thr -9-expression tag
Thr -8-expression tag
Glu -7-expression tag
Asn -6-expression tag
Leu -5-expression tag
Tyr -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Ala 0-expression tag
Ala 33Asn 48engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight42123.8
Non-Polymers*Number of molecules8
Total formula weight770.6
All*Total formula weight42894.4
*Water molecules are not included.

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PDB entries from 2024-03-27

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