6GLL
Crystal structure of hMTH1 N33A in complex with LW14 in the presence of acetate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 7,8-dihydro-8-oxoguanine triphosphatase | polymer | 182 | 21061.9 | 2 | UniProt (P36639) Pfam (PF00293) In PDB | Homo sapiens (Human) | 2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1 |
2 | A, B | 1~{H}-imidazo[4,5-b]pyridin-2-amine | non-polymer | 134.1 | 2 | Chemie (BU8) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
4 | A, B | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
5 | water | water | 18.0 | 410 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 156 (UniProt: P36639)
PDB | External Database | Details |
---|---|---|
Met -25 | - | initiating methionine |
Lys -24 | - | expression tag |
His -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
Pro -17 | - | expression tag |
Met -16 | - | expression tag |
Ser -15 | - | expression tag |
Asp -14 | - | expression tag |
Tyr -13 | - | expression tag |
Asp -12 | - | expression tag |
Ile -11 | - | expression tag |
Pro -10 | - | expression tag |
Thr -9 | - | expression tag |
Thr -8 | - | expression tag |
Glu -7 | - | expression tag |
Asn -6 | - | expression tag |
Leu -5 | - | expression tag |
Tyr -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Gly -1 | - | expression tag |
Ala 0 | - | expression tag |
Ala 33 | Asn 48 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 42123.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 770.6 | |
All* | Total formula weight | 42894.4 |