6GLB
Crystal structure of JAK3 in complex with Compound 20 (FM484)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK3 | polymer | 294 | 33417.3 | 2 | UniProt (P52333) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK |
| 2 | C, H (A, B) | 3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]propanenitrile | non-polymer | 359.4 | 2 | Chemie (F48) | |||
| 3 | D, I (A, B) | 1-phenylurea | non-polymer | 136.2 | 2 | Chemie (PHU) | |||
| 4 | E, F, G, J, K (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 242 | Chemie (HOH) |
Sequence modifications
A, B: 812 - 1103 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Ser 810 | - | expression tag |
| Met 811 | - | expression tag |
| Ala 949 | Asp 949 | conflict |
| Ser 1040 | Cys 1040 | conflict |
| Ser 1048 | Cys 1048 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66834.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1301.5 | |
| All* | Total formula weight | 68136.1 |
