6GL9
Crystal structure of JAK3 in complex with Compound 10 (FM475)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK3 | polymer | 294 | 33417.3 | 2 | UniProt (P52333) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK |
| 2 | C, M (A, B) | (~{E})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | non-polymer | 367.4 | 2 | Chemie (F3W) | |||
| 3 | D, N (A, B) | 1-phenylurea | non-polymer | 136.2 | 2 | Chemie (PHU) | |||
| 4 | E, O (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F, G, H, I, J... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 6 | V, W (A, B) | water | water | 18.0 | 321 | Chemie (HOH) |
Sequence modifications
A, B: 812 - 1103 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Ser 810 | - | expression tag |
| Met 811 | - | expression tag |
| Ala 949 | Asp 949 | conflict |
| Ser 1040 | Cys 1040 | conflict |
| Ser 1048 | Cys 1048 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66834.6 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1998.3 | |
| All* | Total formula weight | 68832.8 |
