6GKD
human NBD1 of CFTR in complex with nanobodies D12 and G3a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J, M... (A, F, I, L, O...) | Cystic fibrosis transmembrane conductance regulator | polymer | 229 | 25525.4 | 6 | UniProt (Q20BJ8) Pfam (PF00005) UniProt (by SIFTS) (P13569) | Homo sapiens (Human) | ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B, E, H, K, N... (B, G, J, M, P...) | Nanobody D12 | polymer | 149 | 16273.9 | 6 | Lama glama | ||
| 3 | C, F, I, L, O... (C, H, K, N, Q...) | Nanobody G3a | polymer | 149 | 16383.9 | 6 | Lama glama | ||
| 4 | S, T, U, V, W (D, E, U, V, W) | alpha-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 5 | In PDB BIRD (PRD_900032) | surcrose isoform | ||
| 5 | AA, EA, GA, IA, MA... (F, I, L, O, R...) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 6 | Chemie (ATP) | |||
| 6 | BA, CA, DA, FA, HA... (F, I, L, O, R...) | MAGNESIUM ION | non-polymer | 24.3 | 10 | Chemie (MG) | |||
| 7 | LA, OA (O, T) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | AB, BB, CB, DB, EB... (N, O, P, Q, R...) | water | water | 18.0 | 226 | Chemie (HOH) |
Sequence modifications
A, F, I, L, O, R: 386 - 646 (UniProt: Q20BJ8)
| PDB | External Database | Details |
|---|---|---|
| Ser 386 | Asn 386 | expression tag |
| - | Phe 405 | deletion |
| - | Gly 406 | deletion |
| - | Glu 407 | deletion |
| - | Leu 408 | deletion |
| - | Phe 409 | deletion |
| - | Glu 410 | deletion |
| - | Lys 411 | deletion |
| - | Ala 412 | deletion |
| - | Lys 413 | deletion |
| - | Gln 414 | deletion |
| - | Asn 415 | deletion |
| - | Asn 416 | deletion |
| - | Asn 417 | deletion |
| - | Asn 418 | deletion |
| - | Arg 419 | deletion |
| - | Lys 420 | deletion |
| - | Thr 421 | deletion |
| - | Ser 422 | deletion |
| - | Asn 423 | deletion |
| - | Gly 424 | deletion |
| - | Asp 425 | deletion |
| - | Asp 426 | deletion |
| - | Ser 427 | deletion |
| - | Leu 428 | deletion |
| - | Phe 429 | deletion |
| - | Phe 430 | deletion |
| - | Ser 431 | deletion |
| - | Asn 432 | deletion |
| - | Phe 433 | deletion |
| - | Ser 434 | deletion |
| - | Leu 435 | deletion |
| - | Leu 436 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 349099.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 1711.5 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3470.3 | |
| All* | Total formula weight | 354281.3 |
