6GHP

14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	14-3-3 protein sigma	polymer	236	26558.9	1	UniProt (P31947) Pfam (PF00244)	Homo sapiens (Human)	Epithelial cell marker protein 1,Stratifin
2	B (P)	Potassium channel subfamily K member 9	polymer	7	883.0	1	UniProt (Q9NPC2)	Homo sapiens	Acid-sensitive potassium channel protein TASK-3,TWIK-related acid-sensitive K(+) channel 3,Two pore potassium channel KT3.2,Two pore K(+) channel KT3.2
3	C (A)	~{N}-[(2~{S})-2-[(1~{E},3~{R},4~{S},8~{R},9~{R},10~{R},11~{S},14~{S})-14-(methoxymethyl)-3,10-dimethyl-8-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(2-methylbut-3-en-2-yloxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,9-bis(oxidanyl)-6-tricyclo[9.3.0.0^{3,7}]tetradeca-1,6-dienyl]propyl]ethanamide	non-polymer		637.8	1	Chemie (EZ5)
4	D (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	E, F (A)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
6	G, H (A, P)	water	water		18.0	244	Chemie (HOH)

Sequence modifications

A: 1 - 231 (UniProt: P31947)

PDB	External Database	Details
Gly -4	-	expression tag
Ala -3	-	expression tag
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

P: 368 - 374 (UniProt: Q9NPC2)

PDB	External Database	Details
Ace 368	Met 368	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	27441.9
Non-Polymers*	Number of molecules	4
	Total formula weight	719.2
All*	Total formula weight	28161.1

*Water molecules are not included.