6GHM

Structure of PP1 alpha phosphatase bound to ASPP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	polymer	329	37349.8	2	UniProt (P62136) Pfam (PF16891) Pfam (PF00149) In PDB	Homo sapiens (Human)	PP-1A
2	C, D	Apoptosis-stimulating of p53 protein 2	polymer	214	24156.2	2	UniProt (Q13625) Pfam (PF00023) Pfam (PF00018) In PDB	Homo sapiens (Human)	Bcl2-binding protein,Bbp,Renal carcinoma antigen NY-REN-51,Tumor suppressor p53-binding protein 2,p53BP2
3	D, A, B	1,2-ETHANEDIOL	non-polymer		62.1	12	Chemie (EDO)
4	A, B	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5	D, A, B	2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID	non-polymer		207.3	6	Chemie (NHE)
6	B, A	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
7		water	water		18.0	245	Chemie (HOH)

Sequence modifications

A, B: 7 - 330 (UniProt: P62136)

PDB	External Database	Details
Gly 2	-	expression tag
His 3	-	expression tag
Met 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag

C, D: 920 - 1128 (UniProt: Q13625)

PDB	External Database	Details
Gly 915	-	expression tag
Pro 916	-	expression tag
Leu 917	-	expression tag
Gly 918	-	expression tag
Ser 919	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	123012.2
Non-Polymers*	Number of molecules	26
	Total formula weight	2576.7
All*	Total formula weight	125588.9

*Water molecules are not included.