6GG4

Crystal structure of M2 PYK in complex with Phenyalanine.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Pyruvate kinase PKM	polymer	551	60204.3	4	UniProt (P14618) Pfam (PF00224) Pfam (PF02887)	Homo sapiens (Human)	Cytosolic thyroid hormone-binding protein,CTHBP,Opa-interacting protein 3,OIP-3,Pyruvate kinase 2/3,Pyruvate kinase muscle isozyme,Thyroid hormone-binding protein 1,THBP1,Tumor M2-PK,p58
2	E, F, H, J, K... (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	8	Chemie (PO4)
3	G, L, P, S (A, B, C, D)	PHENYLALANINE	non-polymer		165.2	4	Chemie (PHE)
4	I, N, Q, T (A, B, C, D)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
5	U, V, W, X (A, B, C, D)	water	water		18.0	353	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 531 (UniProt: P14618)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	240817.0
Non-Polymers*	Number of molecules	16
	Total formula weight	1576.9
All*	Total formula weight	242393.9

*Water molecules are not included.