6GFX
pVHL:EloB:EloC in complex with modified HIF-1a CODD peptide containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 13a)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Elongin-B | polymer | 104 | 11748.4 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B (B) | Elongin-C | polymer | 97 | 10974.6 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | C (C) | von Hippel-Lindau disease tumor suppressor | polymer | 160 | 18558.2 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
| 4 | D (D) | FLUORINATED HYPOXIA-INDUCIBLE FACTOR 1 ALPHA PEPTIDE | polymer | 19 | 2278.4 | 1 | Pfam (PF11413) UniProt (by SIFTS) (Q16665) | Homo sapiens | |
| 5 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
B: 17 - 112 (UniProt: Q15369)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43559.6 | |
| All* | Total formula weight | 43559.6 |
