6GES
Crystal structure of ERK1 covalently bound to SM1-71
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase 3 | polymer | 380 | 43277.6 | 2 | UniProt (P27361) Pfam (PF00069) | Homo sapiens (Human) | MAPK 3,ERT2,Extracellular signal-regulated kinase 1,ERK-1,Insulin-stimulated MAP2 kinase,MAP kinase isoform p44,p44-MAPK,Microtubule-associated protein 2 kinase,p44-ERK1 |
| 2 | C, H (A, B) | N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | non-polymer | 466.0 | 2 | Chemie (6H3) | |||
| 3 | D (A) | ~{N}-[2-[[5-chloranyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide | non-polymer | 464.0 | 1 | Chemie (EWH) | |||
| 4 | E, I (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | F, G, J, K, L (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 312 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 379 (UniProt: P27361)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86555.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1898.4 | |
| All* | Total formula weight | 88453.5 |
