6G9Q
Ternary complex of P14 TCR with murine MHC class I H-2 Db in complex with self-antigen derived from dopamine monooxygenase.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | H-2 class I histocompatibility antigen, D-B alpha chain | polymer | 276 | 32087.7 | 1 | UniProt (P01899) Pfam (PF00129) Pfam (PF07654) In PDB | Mus musculus (House Mouse) | H-2D(B) |
| 2 | B | Beta-2-microglobulin | polymer | 119 | 13795.0 | 1 | UniProt (P01887) Pfam (PF07654) In PDB | Mus musculus (House Mouse) | |
| 3 | G | T cell receptor alpha variable 14-1,T-cell receptor alpha chain C region | polymer | 205 | 23030.7 | 1 | UniProt (A0A0G2JF94) UniProt (P01849) Pfam (PF07686) In PDB | Mus musculus (House Mouse) | |
| 4 | H | T-cell receptor beta chain V region C5,T-cell receptor beta-1 chain C region | polymer | 238 | 26663.6 | 1 | UniProt (P04213) UniProt (P01852) Pfam (PF07686) Pfam (PF07654) In PDB | Mus musculus (House Mouse) | |
| 5 | P | Dopamine beta-hydroxylase | polymer | 9 | 1038.2 | 1 | UniProt (Q64237) In PDB | Mus musculus | Dopamine beta-monooxygenase |
| 6 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
B: -19 - 99 (UniProt: P01887)
G: 1 - 99 (UniProt: A0A0G2JF94)
G: 118 - 205 (UniProt: P01849)
H: 1 - 111 (UniProt: P04213)
H: 112 - 238 (UniProt: P01852)
P: 1 - 9 (UniProt: Q64237)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | Tyr 19 | conflict |
| Gly 0 | Ala 20 | conflict |
| Asp 85 | Ala 105 | variant |
| PDB | External Database | Details |
|---|---|---|
| Leu 100 | - | linker |
| Tyr 101 | - | linker |
| Gly 102 | - | linker |
| Asn 103 | - | linker |
| Glu 104 | - | linker |
| Lys 105 | - | linker |
| Ile 106 | - | linker |
| Thr 107 | - | linker |
| Phe 108 | - | linker |
| Gly 109 | - | linker |
| Ala 110 | - | linker |
| Gly 111 | - | linker |
| Thr 112 | - | linker |
| Lys 113 | - | linker |
| Leu 114 | - | linker |
| Thr 115 | - | linker |
| Ile 116 | - | linker |
| Lys 117 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asn 119 | Tyr 2 | conflict |
| Asp 124 | Glu 7 | conflict |
| Lys 134 | Arg 17 | conflict |
| Cys 166 | Thr 49 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 93 | Gly 103 | conflict |
| Ala 94 | Thr 104 | conflict |
| - | Ala 107 | deletion |
| Arg 97 | Leu 108 | conflict |
| Asn 98 | Asp 109 | conflict |
| Leu 100 | Gln 111 | conflict |
| Ala 104 | Pro 115 | conflict |
| Ser 109 | Leu 120 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 133 | Ala 22 | conflict |
| Cys 168 | Ser 57 | conflict |
| Ser 182 | Cys 71 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Pro 3 | Leu 559 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 96615.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 96707.2 |
