6G98
Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Carbonic anhydrase 9 | polymer | 257 | 28172.7 | 4 | UniProt (Q16790) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase IX,Carbonic anhydrase IX,CAIX,Membrane antigen MN,P54/58N,Renal cell carcinoma-associated antigen G250,RCC-associated antigen G250,pMW1 |
| 2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | A, B, C, D | 4-[2-[3-(cyclododecylamino)-2,5,6-tris(fluoranyl)-4-sulfamoyl-phenyl]sulfanylethyl]benzoic acid | non-polymer | 572.7 | 4 | Chemie (ER5) | |||
| 4 | water | water | 18.0 | 422 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 261 (UniProt: Q16790)
| PDB | External Database | Details |
|---|---|---|
| Pro 3 | Asp 136 | conflict |
| Ser 41 | Cys 174 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 112690.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2552.4 | |
| All* | Total formula weight | 115243.2 |
