6G35

Crystal structure of haspin in complex with 5-bromotubercidin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase haspin	polymer	357	40711.5	1	UniProt (Q8TF76) Pfam (PF12330) In PDB	Homo sapiens (Human)	Germ cell-specific gene 2 protein,H-haspin,Haploid germ cell-specific nuclear protein kinase
2	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
3	A	5-bromotubercidin	non-polymer		345.1	1	Chemie (EKK)
4	A	BROMIDE ION	non-polymer		79.9	1	Chemie (BR)
5	A	COBALT (II) ION	non-polymer		58.9	1	Chemie (CO)
6	A	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	2	Chemie (MPD)
7		water	water		18.0	318	Chemie (HOH)

Sequence modifications

A: 465 - 798 (UniProt: Q8TF76)

PDB	External Database	Details
Met -22	-	initiating methionine
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
Ser -15	-	expression tag
Ser -14	-	expression tag
Gly -13	-	expression tag
Val -12	-	expression tag
Asp -11	-	expression tag
Leu -10	-	expression tag
Gly -9	-	expression tag
Thr -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Ser -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40711.5
Non-Polymers*	Number of molecules	6
	Total formula weight	743.3
All*	Total formula weight	41454.8

*Water molecules are not included.