6G33

Crystal structure of CLK1 in complex with 5-iodotubercidin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dual specificity protein kinase CLK1	polymer	339	39741.5	1	UniProt (P49759) Pfam (PF00069) In PDB	Homo sapiens (Human)	CDC-like kinase 1
2	B, C	Dual specificity protein kinase CLK1	polymer	339	39581.5	2	UniProt (P49759) Pfam (PF00069) In PDB	Homo sapiens (Human)	CDC-like kinase 1
3	A, B, C	(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL	non-polymer		392.1	3	Chemie (5ID)
4	A, B, C	IODIDE ION	non-polymer		126.9	3	Chemie (IOD)
5	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6		water	water		18.0	341	Chemie (HOH)

Sequence modifications

A: 148 - 484 (UniProt: P49759)

PDB	External Database	Details
Ser -1	-	expression tag
Met 0	-	expression tag
Ala 432	Arg 432	variant

B, C: 148 - 484 (UniProt: P49759)

PDB	External Database	Details
Ser -1	-	expression tag
Met 0	-	expression tag
Ala 432	Arg 432	variant

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	118904.5
Non-Polymers*	Number of molecules	7
	Total formula weight	1652.1
All*	Total formula weight	120556.6

*Water molecules are not included.