6G33
Crystal structure of CLK1 in complex with 5-iodotubercidin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity protein kinase CLK1 | polymer | 339 | 39741.5 | 1 | UniProt (P49759) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 1 |
| 2 | B, C (B, C) | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 2 | UniProt (P49759) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 1 |
| 3 | D, G, I (A, B, C) | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL | non-polymer | 392.1 | 3 | Chemie (5ID) PubChem (16760523) PubChem (23919584) PubChem (25880707) PubChem (26248662) PubChem (35028380) PubChem (46875276) PubChem (51386958) PubChem (51537014) PubChem (59583554) PubChem (59583625) PubChem (134695308) PubChem (45039587) PubChem (1830) PubChem (97297) PubChem (6419781) PubChem (9886793) PubChem (14221929) | |||
| 4 | E, H, J (A, B, C) | IODIDE ION | non-polymer | 126.9 | 3 | Chemie (IOD) PubChem (30165) | |||
| 5 | F (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 6 | K, L, M (A, B, C) | water | water | 18.0 | 341 | Chemie (HOH) |
Sequence modifications
A: 148 - 484 (UniProt: P49759)
B, C: 148 - 484 (UniProt: P49759)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 432 | Arg 432 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 432 | Arg 432 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118904.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1652.1 | |
| All* | Total formula weight | 120556.6 |
